Arizona Cardinals vs San Francisco 49ers · 2025 Season
Last updated: April 15, 2026
2 meetings tracked · closing-line graded
Across 2 2025 season meetings, San Francisco 49ers lead 2-0. Games have averaged 47.0 combined points.
RECORD
0-2
MEETINGS
2
ATS
1-1
O / U
1-1
Key Insights
- ▸San Francisco 49ers lead 2-0 across 2 tracked meetings.
- ▸Games have averaged 47.0 combined points.
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Frequently Asked Questions
What is the Arizona Cardinals vs San Francisco 49ers record all-time?▾
Across 2 all-time meetings, the San Francisco 49ers lead the series 2-0.
What is the ATS trend in Arizona Cardinals vs San Francisco 49ers games?▾
ATS: Arizona Cardinals are 1-1 vs the spread in these matchups. San Francisco 49ers are 1-1.
Do Arizona Cardinals vs San Francisco 49ers games go over or under?▾
Over/under: games between Arizona Cardinals and San Francisco 49ers have gone over 1 times and under 1 times, with an average combined score of 47.0.
When did Arizona Cardinals and San Francisco 49ers last play?▾
See Last Meetings section for detailed score, spread, and total data from the most recent Arizona Cardinals vs San Francisco 49ers games.
Where can I see the 5-year Arizona Cardinals vs San Francisco 49ers history?▾
A 5-year head-to-head page tracks every Arizona Cardinals vs San Francisco 49ers meeting from the last five full seasons. Link at the bottom of this page.