Trendline Labs
MLBHead-to-HeadAll-Time

San Diego Padres vs St. Louis Cardinals · All-Time

Last updated: April 15, 2026

45 meetings tracked · closing-line graded

Across 45 all-time head-to-head meetings, San Diego Padres lead 25-20. Games have averaged 8.2 combined points.

RECORD

25-20

MEETINGS

45

ATS

12-14

O / U

9-14

Key Insights

  • San Diego Padres lead 25-20 across 45 tracked meetings.
  • Games have averaged 8.2 combined points.
  • St. Louis Cardinals have been the better ATS side (14-12).
  • Strong Under trend: 9-14 O/U.

Year-by-Year Record

SeasonGamesSan Diego PadresSt. Louis CardinalsATSO / UAvg Total
20257434-34-38.9
20247342-52-47.9
20236334-22-38.7
20226242-41-46.0
202133011.0
202032111.7
20196428.2
20187436.7

Ask Optimus about San Diego Padres vs St. Louis Cardinals

Pick a starter or type your own. First query is free.

First query free

More from this matchup

Frequently Asked Questions

What is the San Diego Padres vs St. Louis Cardinals record all-time?

Across 45 all-time meetings, the San Diego Padres lead the series 25-20.

What is the ATS trend in San Diego Padres vs St. Louis Cardinals games?

ATS: San Diego Padres are 12-14 vs the spread in these matchups. St. Louis Cardinals are 14-12.

Do San Diego Padres vs St. Louis Cardinals games go over or under?

Over/under: games between San Diego Padres and St. Louis Cardinals have gone over 9 times and under 14 times, with an average combined score of 8.2.

When did San Diego Padres and St. Louis Cardinals last play?

See Last Meetings section for detailed score, spread, and total data from the most recent San Diego Padres vs St. Louis Cardinals games.

Where can I see the 5-year San Diego Padres vs St. Louis Cardinals history?

A 5-year head-to-head page tracks every San Diego Padres vs St. Louis Cardinals meeting from the last five full seasons. Link at the bottom of this page.

Data coverage: Trendline's head-to-head records include closing-line-graded games from 20182025. Older meetings aren't in this dataset yet.

Head-to-head data derived from closing-line game records. Stats update nightly from graded game results.

For informational and entertainment purposes only. Not betting advice. Please gamble responsibly.

Optimus

Matchups

Systems

Titan