Trendline
MLBHead-to-HeadAll-Time

San Diego Padres vs St. Louis Cardinals · All-Time

Last updated: April 15, 2026

49 meetings tracked · closing-line graded

Across 49 all-time head-to-head meetings, San Diego Padres lead 27-22. Games have averaged 7.9 combined points.

RECORD

27-22

MEETINGS

49

ATS

13-17

O / U

9-18

Key Insights

  • San Diego Padres lead 27-22 across 49 tracked meetings.
  • Games have averaged 7.9 combined points.
  • St. Louis Cardinals have been the better ATS side (17-13).
  • Strong Under trend: 9-18 O/U.

Year-by-Year Record

SeasonGamesSan Diego PadresSt. Louis CardinalsATSO / UAvg Total
20264221-35.0
20257434-34-38.9
20247342-52-47.9
20236334-22-38.7
20226242-41-46.0
202133011.0
202032111.7
20196428.2
20187436.7

Ask Optimus about San Diego Padres vs St. Louis Cardinals

Pick a starter or type your own. First query is free.

First query free

More from this matchup

Frequently Asked Questions

What is the San Diego Padres vs St. Louis Cardinals record all-time?

Across 49 all-time meetings, the San Diego Padres lead the series 27-22.

What is the ATS trend in San Diego Padres vs St. Louis Cardinals games?

ATS: San Diego Padres are 13-17 vs the spread in these matchups. St. Louis Cardinals are 17-13.

Do San Diego Padres vs St. Louis Cardinals games go over or under?

Over/under: games between San Diego Padres and St. Louis Cardinals have gone over 9 times and under 18 times, with an average combined score of 7.9.

When did San Diego Padres and St. Louis Cardinals last play?

See Last Meetings section for detailed score, spread, and total data from the most recent San Diego Padres vs St. Louis Cardinals games.

Where can I see the 5-year San Diego Padres vs St. Louis Cardinals history?

A 5-year head-to-head page tracks every San Diego Padres vs St. Louis Cardinals meeting from the last five full seasons. Link at the bottom of this page.

Data coverage: Trendline's head-to-head records include closing-line-graded games from 20182026. Older meetings aren't in this dataset yet.

Head-to-head data derived from closing-line game records. Stats update nightly from graded game results.

For informational and entertainment purposes only. Not betting advice. Please gamble responsibly.

Optimus

Matchups

Systems

Titan