Trendline Labs
MLBHead-to-HeadAll-Time

Cleveland Guardians vs St. Louis Cardinals · All-Time

Last updated: April 15, 2026

12 meetings tracked · closing-line graded

Across 12 all-time head-to-head meetings, St. Louis Cardinals lead 8-4. Games have averaged 7.9 combined points.

RECORD

4-8

MEETINGS

12

ATS

4-8

O / U

4-8

Key Insights

  • St. Louis Cardinals lead 8-4 across 12 tracked meetings.
  • Games have averaged 7.9 combined points.
  • St. Louis Cardinals have been the better ATS side (8-4).
  • Strong Under trend: 4-8 O/U.

Year-by-Year Record

SeasonGamesCleveland GuardiansSt. Louis CardinalsATSO / UAvg Total
20263121-22-110.3
20253031-29.0
20243122-11-26.7
20233211-25.7

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Frequently Asked Questions

What is the Cleveland Guardians vs St. Louis Cardinals record all-time?

Across 12 all-time meetings, the St. Louis Cardinals lead the series 8-4.

What is the ATS trend in Cleveland Guardians vs St. Louis Cardinals games?

ATS: Cleveland Guardians are 4-8 vs the spread in these matchups. St. Louis Cardinals are 8-4.

Do Cleveland Guardians vs St. Louis Cardinals games go over or under?

Over/under: games between Cleveland Guardians and St. Louis Cardinals have gone over 4 times and under 8 times, with an average combined score of 7.9.

When did Cleveland Guardians and St. Louis Cardinals last play?

See Last Meetings section for detailed score, spread, and total data from the most recent Cleveland Guardians vs St. Louis Cardinals games.

Where can I see the 5-year Cleveland Guardians vs St. Louis Cardinals history?

A 5-year head-to-head page tracks every Cleveland Guardians vs St. Louis Cardinals meeting from the last five full seasons. Link at the bottom of this page.

Data coverage: Trendline's head-to-head records include closing-line-graded games from 20232026. Older meetings aren't in this dataset yet.

Head-to-head data derived from closing-line game records. Stats update nightly from graded game results.

For informational and entertainment purposes only. Not betting advice. Please gamble responsibly.

Optimus

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